Running Title: Neonatal hyperoxia stimulates AEC II transdifferentiation
نویسندگان
چکیده
Hyperoxia stimulates the transdifferentiation of type II alveolar 1 epithelial cells in newborn rats 2 3 Ana Hou 4 Jianhua Fu 5 Haiping Yang 6 Yuting Zhu 7 Yuqing Pan 8 Shuyan Xu 9 Xindong Xue 10 11 Corresponding author 12 Email: [email protected] 13 Tel: +86 024 96615-1-50131 14 Department of Pediatrics, Shengjing Hospital of China Medical 15 University, Shenyang 110004, China 16 17 18 19 Running Title: Neonatal hyperoxia stimulates AEC II transdifferentiation 20 21 22 Articles in PresS. Am J Physiol Lung Cell Mol Physiol (February 13, 2015). doi:10.1152/ajplung.00099.2014
منابع مشابه
CALL FOR PAPERS Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies Hyperoxia stimulates the transdifferentiation of type II alveolar epithelial cells in newborn rats
Hou A, Fu J, Yang H, Zhu Y, Pan Y, Xu S, Xue X. Hyperoxia stimulates the transdifferentiation of type II alveolar epithelial cells in newborn rats. Am J Physiol Lung Cell Mol Physiol 308: L861–L872, 2015. First published February 13, 2015; doi:10.1152/ajplung.00099.2014.—Supplemental oxygen treatment in preterm infants may cause bronchopulmonary dysplasia (BPD), which is characterized by alveol...
متن کاملHyperoxia stimulates the transdifferentiation of type II alveolar epithelial cells in newborn rats.
Supplemental oxygen treatment in preterm infants may cause bronchopulmonary dysplasia (BPD), which is characterized by alveolar simplification and vascular disorganization. Despite type II alveolar epithelial cell (AEC II) damage being reported previously, we found no decrease in the AEC II-specific marker, surfactant protein C (SP-C), in the BPD model in our previous study. We thus speculated ...
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BACKGROUND Lung alveolar epithelial type II cells (AEC II) are the most important stem cells in lung tissues, which are critical for wound repair of bronchopulmonary dysplasia (BPD). This study investigated the effects of calcitonin gene-related peptide (CGRP) on AEC II cells exposed to hyperoxia. MATERIAL AND METHODS Neonatal rat AEC II cells were isolated and identified by detecting surfactan...
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