Running Title: Neonatal hyperoxia stimulates AEC II transdifferentiation

نویسندگان

  • Ana Hou
  • Jianhua Fu
  • Haiping Yang
  • Yuting Zhu
  • Yuqing Pan
  • Shuyan Xu
  • Xindong Xue
چکیده

Hyperoxia stimulates the transdifferentiation of type II alveolar 1 epithelial cells in newborn rats 2 3 Ana Hou 4 Jianhua Fu 5 Haiping Yang 6 Yuting Zhu 7 Yuqing Pan 8 Shuyan Xu 9 Xindong Xue 10 11 Corresponding author 12 Email: [email protected] 13 Tel: +86 024 96615-1-50131 14 Department of Pediatrics, Shengjing Hospital of China Medical 15 University, Shenyang 110004, China 16 17 18 19 Running Title: Neonatal hyperoxia stimulates AEC II transdifferentiation 20 21 22 Articles in PresS. Am J Physiol Lung Cell Mol Physiol (February 13, 2015). doi:10.1152/ajplung.00099.2014

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

CALL FOR PAPERS Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies Hyperoxia stimulates the transdifferentiation of type II alveolar epithelial cells in newborn rats

Hou A, Fu J, Yang H, Zhu Y, Pan Y, Xu S, Xue X. Hyperoxia stimulates the transdifferentiation of type II alveolar epithelial cells in newborn rats. Am J Physiol Lung Cell Mol Physiol 308: L861–L872, 2015. First published February 13, 2015; doi:10.1152/ajplung.00099.2014.—Supplemental oxygen treatment in preterm infants may cause bronchopulmonary dysplasia (BPD), which is characterized by alveol...

متن کامل

Hyperoxia stimulates the transdifferentiation of type II alveolar epithelial cells in newborn rats.

Supplemental oxygen treatment in preterm infants may cause bronchopulmonary dysplasia (BPD), which is characterized by alveolar simplification and vascular disorganization. Despite type II alveolar epithelial cell (AEC II) damage being reported previously, we found no decrease in the AEC II-specific marker, surfactant protein C (SP-C), in the BPD model in our previous study. We thus speculated ...

متن کامل

Extrinsic Calcitonin Gene-Related Peptide Inhibits Hyperoxia-Induced Alveolar Epithelial Type II Cells Apoptosis, Oxidative Stress, and Reactive Oxygen Species (ROS) Production by Enhancing Notch 1 and Homocysteine-Induced Endoplasmic Reticulum Protein (HERP) Expression

BACKGROUND Lung alveolar epithelial type II cells (AEC II) are the most important stem cells in lung tissues, which are critical for wound repair of bronchopulmonary dysplasia (BPD). This study investigated the effects of calcitonin gene-related peptide (CGRP) on AEC II cells exposed to hyperoxia. MATERIAL AND METHODS Neonatal rat AEC II cells were isolated and identified by detecting surfactan...

متن کامل

Asiaticoside attenuates hyperoxia-induced lung injury in vitro andin vivo

Objective(s): Asiaticoside (AS) displays anti-inflammation, and anti-apoptosis effect, but the role of AS in hyperoxia-induced lung injury (HILI) treatment is undefined. Therefore, the aim of this study was to investigate the effects of AS on HILI on premature rats and alveolar type II (AEC II) cells.Materials and Methods: Sprague-Dawley...

متن کامل

Effect of Substance P on type II alveolar epithelial cells exposed to hyperoxia and its regulation of the Sonic hedgehog signaling pathway.

Oxidative stress injury and cell death in alveolar epithelial cells may lead to abnormal repair, further resulting in acute and chronic pulmonary diseases. Substance P (SP) has multiple biological activities. The Sonic hedgehog (SHH) pathway is important in lung development and decreasing epithelial injury. To investigate the effects of SP on alveolar epithelial type II cells (AEC IIs), AEC IIs...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015